Mechanistic Insights into Xenon Inhibition of NMDA Receptors from MD Simulations
نویسندگان
چکیده
منابع مشابه
Mechanistic insights into xenon inhibition of NMDA receptors from MD simulations.
Inhibition of N-methyl-D-aspartate (NMDA) receptors has been viewed as a primary cause of xenon anesthesia, yet the mechanism is unclear. Here, we investigated interactions between xenon and the ligand-binding domain (LBD) of a NMDA receptor and examined xenon-induced structural and dynamical changes that are relevant to functional changes of the NMDA receptor. Several comparative molecular dyn...
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ژورنال
عنوان ژورنال: The Journal of Physical Chemistry B
سال: 2010
ISSN: 1520-6106,1520-5207
DOI: 10.1021/jp101687j